What is Metabolic Detoxification?
Metabolic detoxification is a natural process for your body to remove toxins from your body cells and ultimately eliminating them from your body. This complex process consists of three phases that convert toxins to water-soluble molecules and then eradicate them.
Excessive hormones, environmental toxins and xenobiotic materials from prescription drugs are all cleared through the same enzyme detoxification systems. Metabolic detoxification is therefore critical to safeguard the body from various exposures and to maintain internal homeostasis.
Natural therapies, vitamins and sulforaphane can help to promote pathways of detoxification by promoting the action of critical enzymes.
How Does Your Body Detoxify Itself?
The natural metabolic detoxification process has three major stages:
Stage I—In this enzymatic transformation process, the sole purpose of your body is to chemically transform compounds from lipid-soluble into more water-soluble. This process is generally carried out by cytochrome P450 enzymes.
Stage II—Then comes enzymatic conjugation where enzymes like UDP-glucuronyltransferases, glutathione S-transferases, and sulfotransferases further increase the water solubility of stage I products and decrease their reactivity.
Stage III—At the very end by the help of ATP-binding cassette transporters, these water-soluble toxic materials are transported out of your body cells.
How can you reduce Exposure to Toxins?
(i) Avoid using carpets and other synthetics as flooring. You can use wooden or tiles floor.
(ii) Use phthalate or bisphenol A free plastic containers and avoid heating food in plastic.
(iii) Choose organic fruits and vegetables if possible
(iv) Wash fruit and vegetables in warm water before eating.
(v) Limit the intake of processed and fast foods. Eat homemade food as much as possible.
(vi) Cook food at low temperature for a long time without charring the food.
If You Know The Chemistry Behind It, You Can Detoxify Your Body By Some Simple Tricks and Tweaks Naturally.
Deficiencies in vitamins A, B complex, C and E are related to reduced development in stage I. They may delay the metabolism of some medications. Vitamin B is also especially important as a cofactor in stage II reaction.
Mineral deficiencies like iron, calcium, copper, zinc, magnesium, and selenium have been shown to reduce stage I enzymatic activity.
Amino acids like methionine and cysteine also play an essential role in detoxification. The reduced glutathione requires adequate sulphur-containing amino acids like methionine or cysteine for proper detoxification.
Onion and tea are the primary dietary source of flavonoids. Flavonoids help in the inhibition of multiple cytochrome P450 in animals. It helps when stage II enzymes are overloaded.
Broccoli and other cruciferous vegetables contain sulforaphane, an isothiocyanate. It is one of the most potent natural inducers of phase II detoxification enzymes.
N-acetyl cysteine can provide sulphur for the synthesis of glutathione. It reduces oxidative stress mainly because of metal toxicity.
Silymarin is a milk thistle derivative. It promotes detoxification mechanisms by acting as an antioxidant. It helps to lower down the liver oxidative stress associated with toxin metabolism that stores glutathione levels.
A variety of natural products like epigallocatechin gallate, resveratrol, curcumin and its metabolite tetrahydrocurcumin, alpha-lipoic acid, alpha-tocopherol, lycopene and ginkgo Biloba increases stage II enzyme production.
0 Comments